Friday, 30 June 2017

Snakebite First Aid for lay people: A Systematic Review

From time to time all of us read on the new spectacular first-aid or treatments done by trained doctors on aircraft's emergencies or any other special circumstances. But, most of the times, first aid has to be applied by laypeople, that just happened to be there.

The present article is a research on the medical publications for those effective measures to be specified as Snakebite first aid guidelines for laypeople. 


The Treatment of Snake Bites in a First Aid Setting: A Systematic Review

Bert Avau(1), Vere Borra(1), Philippe Vandekerckhove (1,2,3) Emmy De Buck (1,2)
1 Centre for Evidence-Based Practice (CEBaP), Belgian Red Cross-Flanders, Mechelen, Belgium, 2 Department of Public Health and Primary Care, Faculty of Medicine, KU Leuven, Leuven, Belgium, 3 Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium

PLOS Neglected Tropical Diseases | DOI:10.1371/journal.pntd.0005079 October 17, 2016 http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005079
This is an Open Access Article.

ABSTRACT

The worldwide burden of snakebite is high, especially in remote regions with lesser accessibility to professional healthcare. Therefore, adequate first aid for snakebite is of the utmost importance. A wide range of different first aid techniques have been described in literature, and are being used in practice. This systematic review aimed to summarize the best available evidence concerning effective and feasible first aid techniques for snakebite. 

Methods
A systematic literature screening, performed independently by two authors in the Cochrane Library, MEDLINE and Embase resulted in 14 studies, fulfilling our predefined selection criteria, concerning first aid techniques for snakebite management. Data was extracted and the body of evidence was appraised according to the GRADE approach. 

Principal findings 
The pressure immobilization technique was identified as the only evidence-based first aid technique with effectiveness on venom spread. However, additional studies suggest that proper application of this technique is not feasible for laypeople. Evidence concerning other first aid measures, such as the application of a tourniquet, suggests avoiding the use of these techniques. 

Conclusions
The practical recommendation for the treatment of snakebite in a first aid setting is to immobilize the victim, while awaiting the emergency services. However, given the low to very low quality of the data collected, high quality randomized controlled trials concerning the efficacy and feasibility of different variations of the pressure immobilization technique are warranted. 

AUTHOR SUMMARY 
The Belgian Red Cross-Flanders develops first aid guidelines that specifically target lay- people. In the context of updating the first aid guidelines for sub-Saharan Africa, we aimed to summarize the best available evidence for the treatment of snakebite, feasible for lay people. Of the numerous first aid measures supported in literature and used in practice, we could only find evidence concerning effectiveness for the pressure immobilization technique on the spread of snake venom, which involves application of a firm pressure bandage on the bitten limb, together with immobilization of the limb. However, studies concerning its feasibility suggest this technique is difficult for laypeople to apply correctly. Keeping the limb immobilized on the other hand had a beneficial effect on the spread of the venom. However, given the low to very low quality of the evidence, high quality trials concerning the effectiveness and feasibility of different variations of the pressure immobilization technique are needed. 

The high burden of snakebite and the fact that snakebite mostly occurs in rural areas, with less accessibility to professional health care and therefore rapid antivenom therapy, illustrate that adequate first aid treatments are of the utmost importance for achieving a positive outcome on both mortality and morbidity after a snakebite. 


In literature, many different techniques, and a combination thereof, are claimed to be effective for the treatment of snakebite. These include:

Techniques suggested to deactivate the venom: 
such as the application of electroshocks, cryotherapy or the use of traditional medicine and concoctions, a collection of practices where mixtures of herbs, oils and other products are being ingested or applied to the bite wound. 

Techniques which are supposed to remove venom from the bite wound: 
include suction of the wound, by mouth or specialized suction devices, incision/excision of the bite wound, irrigation of the bite wound, or the use of “snake stones”, which are believed to absorb the poison out of the wound. 

Methods proposed to limit the spread of the venom: 
in the body include application of a tourniquet, which completely blocks the blood flow to the bitten limb, and the pressure immobilization technique. The latter technique involves application of a pressure bandage at sufficiently high pressures to block lymphatic flow, but without actually applying a tourniquet, together with immobilization of the bitten limb. 

This systematic review is the first in its kind to synthesize the available evidence concerning suggested first aid measures for snakebite, thus facilitating evidence-based decision making during the development of snakebite first aid guidelines for laypeople. 

Question:
"In people with snakebites, is a certain first aid intervention, compared to another first aid intervention or no intervention, effective and feasible for laypeople as a first aid treatment to increase survival, tissue healing, functional recovery, pain, complications, time to resumption of usual activity, restoration to the pre-exposure condition, time to resolution of the symptoms or other health outcome measures (including adverse effects)?











Process of study selection:
The searches and study selection procedures were performed independently by two reviewers (BA and VB). Any discrepancy between the reviewers was resolved by consensus or by consulting a third reviewer (EDB).
A search in The Cochrane Library, MEDLINE and Embase resulted in a total of 3,893 retrieved references. (After removing 956 (BA) and 1,132 (VB) duplicates, the titles and abstracts of 2,928 (BA) and 2,761 (VB) records were screened on relevance regarding the PICO question. For 81 (BA) and 101 (VB) publications, a full-text was obtained and eligibility was assessed, resulting in 12 articles that matched the predefined selection criteria. The majority of publications excluded had an inappropriate study design. A search in the references and similar articles lists of these publications resulted in 2 additional publications matching the selection criteria, leading to a total of 14 included articles.

Characteristics of the included studies
Of the 14 included articles, 7 were experimental and 7 were observational studies. 4 experimental studies evaluated the efficacy of variants of the pressure immobilization technique, on simulated snake bites while 3 others examined the feasibility of pressure immobilization to be performed by laypeople. The observational studies all examined the outcomes of different applied first aid procedures in snakebite patients. 




Synthesis of findings from the included studies:
EXPERIMENTAL STUDIES
1) Pressure immobilization: 
Experimental studies used measuring the time to reach 80% of the maximal radioactivity in the blood after mock venom injection as outcome for comparing different times of pressure immobilization techniques. 

Pressure immobilization using an elastic bandage with a splint was not shown to be effective as the results were almost the same than for the controls. In contrast, using a firmly bound cloth pad over the site of injection really delayed the time to reach 80% (p<0.001). The use of a firmly bound rubber pad over the site of injection together with splinting delayed the time for the mock venom to reach 80% radioactivity (p<0.001). 

Pressure pad + immobilization Dr. David J. Williams
In another study comparing the amount of radioactivity in the blood after 60min, as % of the maximal radioactivity measured, again the elastic bandage with splinting was significantly different to no treatment while a firmly bound cloth pad was found to be effective (p<0.00001). 

Another data important data obtained (Howarth et al.) was that rest resulted in a significant decrease in the proportion of volunteers with tracer transit compared to the proportion of volunteers with tracer transit while walking. 

Furthermore, training is needed for the correct application of the elastic bandages to get the proper pressure and even there is a high lack of retention of the ability of correctly apply the elastic bandage.



OBSERVATIONAL STUDIES
I would like to focus on the clinical studies (a total of 7) and I had a kind of difficult time trying to understand the paper, So finally I tried to found the reviewed articles on the internet with more or less good luck. See what I've found
For a better understanding I'm including the abstract available. There is only one full text article available. 

Bibliography list: 13, 16, 22, 30, 31, 32, 33


13: Madaki JKA, Obilom RE, Mandong BM (2005) 
Pattern of First-Aid Measures Used by Snake-bite Patients and Clinical Outcome at Zamko Comprehensive Health Centre, Langtang, Plateau State. 
Nig Med Pract 48: 10–13.
Abstract 
The use of first aid measures in the management of snake bite by patients in rural communities in Africa is a popular practice. Records of 103 snake bite patients admitted at Zamko Comprehensive Health Centre, were retrieved and reviewed. 84 (81.6%) of the 103 cases with snake bite used first aid measures. Common first aid measures employed include tourniquet (ropes, pieces of cloth), use of the black stone, application of traditional medicine and incision of site of bites. The use of first aid measure did not prevent spread of the venom. There was no significant increase in the proportion of patients with tissue necrosis between patient that used tourniquet and those that did not (7.9% vs 5.3%). Patients that did not employ first aid measures required significantly higher doses (mls) of antivenom compared to those who used tourniquet (39.33 Vs 24.52 P< 0.01); those who use traditional medicine (39.33 Vs 27.5 P < 0.01); and those who used black stone (39.33 Vs 28.75 P < 0.01). Also those who used the black stone required significantly higher quantity of antivenom as compared to those that used the tourniquet (28.75 vs 24.52 P < 0.05). The use of the tourniquet, traditional herbs and the black stone appears to have beneficial effects by reducing the average antivenom requirement of patients and more studies are needed to identify the most appropriate approaches to their use.


16: Michael GC, Thacher TD, Shehu MI. The effect of pre-hospital care for venomous snake bite on outcome in Nigeria. Trans R Soc Trop Med Hyg 2011;105: 95–101
Abstract 
We studied pre-hospital practices of 72 consecutive snake bite victims at a hospital in north-central Nigeria. The primary outcome assessed was death or disability at hospital discharge. Victims were predominantly male farmers, and in 54 cases (75%) the snake was identified as a carpet viper (Echis ocellatus), with the remainder unidentified. Most subjects (58, 81%) attempted at least one first aid measure after the bite, including tourniquet application (53, 74%), application (15, 21%) or ingestion (10, 14%) of traditional concoctions, bite site incision (8, 11%), black stone application (4, 5.6%), and suction (3, 4.2%). The majority (44, 61%) presented late (after 4 hours). Most (53, 74%) had full recovery at hospital discharge. Three deaths (4.2%) and thirteen (18%) disabilities (mainly tissue necrosis) occurred. The use of any first aid was associated with a longer hospital stay than no use (4.6 ± 2.0 days versus 3.6 ± 2.7 days, respectively, P = 0.02). The antivenom requirement was greater in subjects who had used a tourniquet (P = 0.03) and in those who presented late (P = 0.02). Topical application (Odds Ratio 15, 95% CI 1.4-708) or ingestion of traditional concoctions (OR 20, 95% CI 1.4-963) were associated with increased risk of death or disability. Ingestion and application of concoctions were associated with a longer time interval before presentation, a higher cost of hospitalization, and an increased risk of wound infection.


22: Amaral CF, Campolina D, Dias MB, Bueno CM, Rezende NA. Tourniquet ineffectiveness to reduce the severity of envenoming after Crotalus durissus snake bite in Belo Horizonte, Minas Gerais, Brazil. Toxicon 1998;36: 805–808
Abstract 
Clinical and laboratory data from patients who applied a tourniquet (tourniquet group, n = 45) and who did not apply it (non-tourniquet group, n = 52) after being bitten by Crotalus durissus were compared. The patients were treated with 100-200 ml of Crotalus durissus antivenom. The gender, age, time elapsed between bite and hospital admission, dose of antivenom and the frequency of local paresthesia, myalgia and palpebral ptosis did not differ between the two groups. Plasma creatine kinase enzyme activity and partial thromboplastin time, plasma whole venom and crotoxin concentrations and the frequency of acute renal and respiratory failure and number of deaths also did not differ between both groups. Data from this study show the ineffectiveness of tourniquet applied by patients in the fields to reduce the severity of Crotalus durissus envenoming.


30: Bhat RN. Viperine snake bite poisoning in Jammu. J Indian Med Assoc 1974;63: 383–392
Nor Abstract / No Article available

31: Franca FO, et al. Envenoming by Bothrops jararaca in Brazil: association between venom antigenaemia and severity at admission to hospital. Trans R Soc Trop Med Hyg 2003;97: 312–317
Abstract
The association between the clinical severity of Bothrops jararaca envenoming at admission and serum venom and plasma fibrinogen concentrations before antivenom administration is reported in 137 patients admitted to Hospital Vital Brazil, Instituto Butantan, São Paulo, Brazil, between 1989 and 1990. Other variables such as age, gender, site of the bite, use of tourniquet and the time interval between the bite and start of antivenom therapy, spontaneous systemic bleeding, and the 20 minute whole blood clotting test (20WBCT) at admission showed no association with either severity or serum venom antigen concentration (SVAC). Mean SVAC in patients with mild envenoming was significantly lower than in the group with moderate envenoming (P = 0.0007). Patients with plasma fibrinogen concentrations > 1.5 g/L had a lower mean SVAC than patients with plasma fibrinogen concentrations < or = 1.5 g/L (P = 0.02). Those admitted with a tourniquet in place had significantly higher plasma fibrinogen concentrations than those without a tourniquet (P = 0.002). A multiple logistic regression model showed independent risk factors for severity: bites at sites other than legs or forearms, SVACs > or = 400 ng/mL, and the use of a tourniquet. Rapid quantification of SVAC before antivenom therapy might improve initial evaluation of severity in B. jararaca bites.


32: Khin OL, Aye AM, Tun P, Theingie N, Min N. Russell's viper venom levels in serum of snake bite victims in Burma. Trans R Soc Trop Med Hyg 1984;78: 165–168
Abstract
Serum levels of venom antigen were measured using enzyme-linked immunosorbent assay (ELISA) in 38 Russell's viper bite victims before and after administration of 40 ml of monovalent liquid antivenom. Initial serum levels ranged from one with less than 10·0 ng to 290 ng/ml and in one case a level of 75 ng/ml was detected 27 hours after the bite. Serum venom levels after liquid monospecific antivenom therapy indicated that venom clearance was similar in each case to the natural clearance of venom in the absence of antivenom therapy. In one case a venom level of 11·5 ng/ml was detected 66 hours after liquid antivenom therapy whereas in two fatal cases, serum venom levels of 95 ng/ml and 185 ng/ml were detected after the same interval. Failure of complete neutralization of venom is probably the result of loss of potency of antivenom during improper storage. The amount of venom excreted in the urine was not related to initial serum levels.


33: Wang W, Chen QF, Yin RX, Zhu JJ, Li QB, Chang HH, Wu YB, Michelson E. Clinical features and treatment experience: a review of 292 Chinese cobra snakebites. Environ Toxicol Pharmacol 2014;37: 648–655
Abstract
Although Chinese cobra snakebite is the most common type of snake venenation in China, it still lacks a comprehensive and systematic description. Hence, we aimed to study Chinese cobra bite cases with particular attention to demography, epidemiology and clinical profile. In this study, a total of 292 cases of Chinese cobra snakebite, presenting between January 1, 2008 and December 31, 2012, were retrospectively reviewed. To investigate the effect of treatment at different presentation times (time from snakebite to admission), the patients were divided into two groups: group A included 133 cases that presented <12h after the bite; group B included 159 cases that presented ≥12h after the bite. To assess the correlation between application of a tourniquet and skin grafting, the cases were re-divided into two groups according to whether or not a tourniquet was used after the snakebite: tourniquet group (n=220) and non-tourniquet group (n=72). The results showed that Chinese cobra snakebites were most commonly seen during the summer, in the upper limbs, and in males, young adults, and snake-hunters. Group A experienced milder intoxication than group B (P<0.001). The rate of skin grafting was significantly higher in the tourniquet group (20.0%, compared with 9.7% in the non-tourniquet group, P<0.05). The results of this study indicate that anti-cobra venom and swift admission (within 12h of the snakebite) are recommended for Chinese cobra snakebite. Tourniquet use is not recommended. 
You can download full article here:


2) TOURNIQUET (13,16,22,30,31,32,33)
The study by Bhat found a significantly increased incidence of local swelling in snakebite victims treated with a tourniquet ,p<0.001) or a tourniquet with incisions in the wound p<0.001), compared to snakebite victims receiving no first aid [30]. 

França et al. described a significantly increased odds for an increased severity of local envenomation in snakebite victims receiving a tourniquet, compared to those not receiving a tourniquet (p = 0.015) [31]. 


Furthermore, Wang et al. showed a significantly increased risk of skin grafting needed in snakebite victims treated with a tourniquet (44/220), compared to those not treated with a tourniquet (7/72, RR: 2.06, p = 0.046) [33].

No significant differences were found between snakebite victims treated with a tourniquet (with or without additional incisions in the bite wound) and victims who received no tourniquet or no first aid for the following outcomes: 
acute renal failure p = 0.75) [22], 
acute respiratory failure p = 0.67) [22], 
death (p = 0.77) [22], 
local edema (p = 0.95) [22], 
occurrence of hemorrhagic syndrome (p = 0.62) [30], 
concentration of venom in the serum (p = 0.38) [32] ([p = 0.16) [31], 
incidence of multiple organ dysfunction syndrome (p = 0.31) [33], 
incidence of envenoming (p = 0.66) [13],
tissue necrosis (p = 0.74) [13] 
occurrence of death or disability (p = 0.16) [16].

Inconclusive evidence exists concerning the effects of tourniquet use on the duration of hospital stay. Madaki et al. found no significant difference in the duration of hospital stay between snakebite victims treated with a tourniquet and those receiving no first aid (6±2.6 days vs 6.3±3 days,p = 0.71), while Michael et al. described a significant increase in the duration of hospital stay between snakebite victims treated with a tourniquet and those receiving no first aid (4.6±2.0 days vs 3.7±2.5 days, MD = 0.9, p = 0.04) [13,16]. 
Conflicting evidence was reported concerning the effects of tourniquet use on the amount of antivenom required. Amaral et al. reported no difference in the amount of antivenom required between snakebite victims treated with or without a tourniquet (139±56.4 mL vs 156.5±65.8 mL, MD = -17.5, 95%CI [-41.82;6.82], p = 0.16), while Madaki et al. found a significantly decreased amount of antivenom required in snakebite victims receiving a tourniquet (24.52±13.6 mL), compared to snakebite victims receiving no first aid (39.33±34.32 mL, MD = -14.81, p<0.01) and Michael et al. found a significantly increased amount of antivenom required in snakebite victims receiving a tourniquet compared to those receiving no tourniquet (p = 0.03)


3) INCISION OF THE BITE WOUND: (16,30) 
Bhat investigated the effects of incision of the bite wound, compared to no first aid treatment and found a significantly increased incidence of local swelling upon incision ( p<0.0001), but not of hemorrhagic syndrome (p = 0.53) [30]. 
Furthermore, Michael et al. reported no difference between snakebite victims with incisions in the bite wound compared to victims receiving no first aid in the incidence of death or disability (p = 0.53) or between snakebite victims with incisions in the bite wound compared to victims not receiving incisions in the bite wound for the amount of antivenom required (p = 0.71) [16]. 
On the other hand, a statistically significant decrease in the duration of hospital stay in snakebite victims receiving incisions in the bite wound compared to not receiving incisions in the bite wound (2.9±1.6 days vs 4.6±2.2 days, MD = -1.70, p = 0.03) was demonstrated.

Here I'm confused. As the abstract says "The use of any first aid was associated with a longer hospital stay than no use (4.6 ± 2.0 days versus 3.6 ± 2.7 days, respectively, P = 0.02)". If the advantage was so clear, I imagine they would have said that but... do not have the full text...


4) SNAKE STONES: (13,16) 
Madaki et al. could not show a significantly decreased incidence of envenoming in snakebite victims using snake stones compared to those receiving no first aid (p = 0.87) [13]. Furthermore, a significantly decreased duration of hospital stay in snakebite victims treated with snake stones compared to those not receiving first aid (6.1±3.3 days vs 6.3±3 days, p = 0.87) or to those not being treated with snake stones (2.5 vs 4, median, p = 0.09) could not be demonstrated [13,16]. Also a difference in the occurrence of death or disability between snakebite victims treated with snake stones or those receiving no first aid could not be demonstrated (p = 0.11) [16]. 
In contrast, inconclusive results were reported for the amount of antivenom required. Madaki et al. reported a significantly decreased amount of antivenom required in snakebite victims treated with snake stones compared to those receiving no first aid (28.75±20.31 mL vs 39.33±34.32 mL, MD = -10.58, p<0.05), while Michael et al. reported no significant differences in the amount of antivenom required between snakebite victims treated with snake stones and those not treated with snake stones (30.0 [15;35] vs 20.0 [15;35], median[IQR], p = 0.71) [13,16]. 


5) TRADITIONAL MEDICINE AND CONCOCTIONS: 
In the study of Madaki et al., the use of traditional medicine (both ingested or applied to the bite wound) in snakebite victims was not found to be significantly associated with a decreased occurrence of envenoming, compared to receiving no first aid (p = 0.94) [13]. Furthermore, a decreased duration of hospital stay could not be demonstrated in snakebite victims receiving traditional medicine, compared to those receiving no first aid (6.9±2.6 days vs 6.3±3.0 days, MD = 0.6, 95%CI [-1.23;2.43], p = 0.52). 

This latter finding was confirmed by Michael et al., who observed no significant difference in the duration of hospital stay between snakebite victims treated with concoctions applied to the bite wound, compared to snakebite victims with no concoctions applied to the bite wound (5 vs 4, median, p = 0.6) or snakebite victims treated with concoctions ingested, compared to snakebite victims with no concoctions ingested (4 vs 4, median, p = 0.84) [16].
In contrast, a significantly increased odds for death or disability was shown in snakebite victims treated with concoctions applied to the bite wound (8/15), compared to snakebite victims with no concoctions applied to the bite wound (p = 0.01) and snakebite victims treated with concoctions ingested (6/10), compared to snakebite victims with no concoctions ingested (p = 0.009) [16]. 
Inconclusive reports were made concerning the use of traditional medicine and concoctions in snakebite victims on the amount of antivenom required. Madaki et al. reported a significantly decreased antivenom requirement in snakebite victims receiving traditional medicine, compared to those receiving no first aid (27.5±23.63 mL vs 39.33±34.32 mL, MD = -11.83, p<0.01), while Michael et al. found no significant difference in antivenom requirement between snakebite victims treated with applied concoctions, compared to those not treated with applied concoctions (p = 0.07) or snakebite victims treated with ingested concoctions, compared to those not treated with ingested concoctions (30.0 [20;30] vs 20.0 [10;40], median[IQR], p = 0.13) 


6) SUCTION OF THE BITE WOUND: 
The study by Michael et al. compared the effect of suction of a bite wound, and found no significant difference in the occurrence of death or disability, compared to no first aid (0/3 vs 1/15, RR: 1.33, 95%CI [0.07; 26.98], p = 0.85) [16]. Furthermore, a significant difference could not be demonstrated between snakebite victims treated by suction of the wound, compared to snakebite victims not treated by suction of the wound, concerning the amount of antivenom required (p = 0.45) or the duration of hospital stay (p = 0.7). 


Quality of evidence
Experimental studies concerning the efficacy of pressure immobilization. 
The final level of quality for the experimental studies concerning the efficacy of pressure immobilization is “very low”, which means that any estimate of effect is very uncertain. 
Experimental studies concerning the feasibility of pressure immobilization to be performed by laypeople. 
The final level of quality for the experimental studies concerning the feasibility of pressure immobilization is “low”, which means that further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. 


Observational studies concerning first aid measures applied in real-life snakebite. 
The 7 studies included were observational studies, leading to an initial “low” quality level The quality of evidence was downgraded for limitations in study design or execution. 

In addition, the overall quality of evidence was also downgraded because of imprecision due to limited sample sizes, low numbers of events and large variability of the results. There was no need to downgrade due to indirectness, inconsistency or a risk of publication bias. Therefore, the final level of quality for the observational studies concerning first aid measures is “very low”, which means that any estimate of effect is very uncertain. 

Discussion
The experimental studies all concern the pressure immobilization technique, based on the use of a crepe or elastic bandage. This technique received a lot of attention in Australia, and is being recommended in official Australian first aid guidelines. However, the effectiveness of this technique has only been demonstrated in animal models with evidence from human studies being limited to case reports.
The feasibility of correctly applying pressure immobilization using an elastic bandage is questionable, especially regarding the tension generated. Intense training is warranted, but even then, retention is low. 

Furthermore, it needs to be taken into account that the pressure immobilization technique might not be appropriate for any type of snake venom. 

For tourniquets, most outcomes that were studied show no benefit of using a tourniquet in snakebite victims. 


The evidence available for other first aid measures is scarce. In conclusion, these alternative methods for the treatment of snakebite are most likely not beneficial and perhaps even harmful. 
Most of these management strategies are applied by traditional healers, who might be preferred over healthcare professionals in first instance. The use of this type of ineffective pre-hospital care might cause a delay in the presentation of the snakebite victim to healthcare facilities, further increasing the detrimental impact of the snakebite on morbidity and mortality. 
Habib et al. previously showed a 1% increase in odds of dying from snakebite for every 1 h delay in healthcare facility presentation in a case-control study of snakebite victims in north-eastern Nigeria [40]. Evidence concerning the time to application for specific first aid measures and their influence on the timing of presentation at a healthcare facility is currently unavailable.

This systematic review has some limitations. 
Thus, the overall quality of the available evidence was low to very low, according to the GRADE approach [21]. 

The evidence collected in this systematic review has been used for the development of a first aid guideline for sub-Saharan Africa [41], according to the principles of Evidence-Based Practice [19], which is being updated in 2016. 
No new evidence, concerning first aid treatments for snake bites, could be identified in the 2016 update. 

Conclusion
Remove any rings, tight clothes...

This systematic review on first aid measures for the treatment of snakebite by lay first aid providers, has revealed that none of the in the literature suggested measures is proven to be both effective and feasible for the treatment of snakebite. 


here is the link for the lay people on snake bite first aid published in 2010 by the Belgium Red Cross. 


Recommendation based on the evidence: 
If the bite is in the leg: immobilize the leg by bandaging it to the other leg.
Additional recommendations based on good practice points: 
stop the bitten person from moving, calm the person, take off any rings, watches, or tight clothing that may cut off blood ow because of swelling, and take actions to obtain medical help.

OK. Done! I really value all the effort the authors did and I do like very much the concept and that the results should be applicable by lay people. One comment: Really, from almost 3,000 articles only 14 were fulfilling the criteria??? really??? That is only a 0,5% 
Some commentaries I do have:
Two or the articles were from Nigeria (Madaki 13 and Michael 16) with completely different results. 
Why do not include in the study the time to reach hospital? 
The pressure pad technique that really, really was significant should be more differentiate from the pressure bandage. Sound almost the same but they are not. Effort should be done on this technique as seems really useful. 
Application of the findings should be country specific and even region specific, like in the case of the pressure bandage that should be applied only for Australian elapids. 

Well, that's all friends, need some dose of humor!!!



ॐ लोकाः समस्ताः सुखिनो भवन्तु ॥
Om Lokah Samasthah Sukhino Bhavantu
May all beings everywhere be happy and peaceful


























































































Monday, 12 June 2017

Tie, Cut and Suck: a worldwide missconception


As said in the last post, I will go through the WHO snakebite guidelines 2016 to see what do the studies / publications have to say about the selected text. Let's start with the first statement:

WHO Guidelines for the Management of Snakebites. 
Searo Region 2016
 pg. 14 

"First-aid: most of the familiar methods for first-aid treatment of snakebite, both western and “traditional / herbal”, have been found to result in more harm (risk) than good (benefit) and should be firmly discouraged". 


"Familiar" methods could be understood by "popular", what most of us considered the appropriate thing to do. If we do now a poll on street people, what will they answer? and from where is this answer coming from? did they watch it on a movie? somebody told them? studied at the school? did a first-aid training?
The top three worldwide misconceptions are: Tie, Cut and Suck.

Recently I read the post of a blogger (stellaV) on the episode (10th of May) of ZKM, a popular Indian soap opera.
A cobra bites the female main character in the hand in a house (in this case a luxury house as the bite is non-accidental). And what do they do? the male character, the husband, ties a cloth, cuts the wound and sucks the venom (all this takes about 10 minutes (zoom in and out... music... never ending!). The wife fully recovers, awakening like a princess coming from a dream, after some miraculous Ayurveda drops are instilled into her mouth.... and yes, they call a doctor which appears in a hurry, writes the prescription of something in 5 sec. and leaves the scene as fast as he arrived... 

And this is one of stellaV's reflections:
"This is criminal, to show such a lax attitude in treatment of medical emergencies. Are they even aware that some people might actually try whatever they just showed today instead of going for the treatment which is required for snake bite...They are spreading this nonsense openly on national television.
I apologize for my rants but it was just too much for me"
http://www.india-forums.com/forum_posts.asp?TID=4844882

Most probably they get more audience on this way that by showing the main actor doing a pressure pad with immobilization... could be, but it seems necessary a kind of regulation as thousands of people watch those programs and a correct first aid can be the difference between life and death. 
As my mother says, it is like keeping sugar and ants together. We do awareness campaigns, with a lot individual efforts, small groups of people, schools, and very vocational, and then they show that on TV! At least the good news is that there was a reaction and some followers agreed too. Thank You StellaV!

On another very recent YouTube video about "Home remedies and Snakebite First Aid", the voice in off advices to "deep cut the wound" and to mix "onion and kerosene" and apply it to wound... make the victim vomit using ghee... and more things of that kind while the video shows messages like immobilize, do not cut, keep calm... that they "cut and paste" from other websites, totally contradictory, absolutely non-sense... 

I would like to refer here to some articles that approach the first aid measures from a general point of view, and when we reach the specific measures like "do not disturb the wound", go into each of them with more detail. 




A Survey of Snakebite Knowledge among Field Forces in China



Int. J. Environ. Res. Public Health 2017, 14(1), 15; doi:10.3390/ijerph14010015
Chulin Chen, Li Gui *, Ting Kan, Shuang Li and Chen Qiu
Department of Emergency Nursing, School of Nursing, Second Military Medical University, Shanghai 200433, China


This is an Open Access Article. Please refer always to this link:
http://www.mdpi.com/1660-4601/14/1/15/htm

Abstract
Background: A snakebite is a neglected extrinsic injury associated with high morbidity and global mortality. Members of Chinese field forces are at high risk of snakebites, and their perception and knowledge of snakebites are unknown. 

The aim of this study is to assess perception and knowledge of snakebites in field forces in southeast China; 

Methods: A cross-sectional questionnaire-based survey was conducted in July 2016. A total of 216 field force members participated in this study; 

Results: A total of 10.3% had experienced snakebites and 86.4% rated their demands for knowledge about snakebite as “high”. No significant correlation between the actual and perceived snakebite knowledge status was detected (κ = 0.0237, p = 0.3852). 
Ineffective and harmful traditional first-aid methods, such as the application of tourniquets, sucking the venom out of the wound, and making local incisions, were used by more than three quarters of the respondents. However, pressure immobilization bandages were applied by only 17.3% of members. 
The proportion of responses for each question was not significantly different among the respondents when considering separate demographic groups; 
Conclusions: Snakebite knowledge among Chinese field force members is inadequate and in some cases misleading, when focusing on manifestation, prevention, and first-aid. A pragmatic, intensive educational scheme should be undertaken in at-risk populations.


Chinese character for Snake
In China, most of the snakes are distributed in the south and southeast of the country. 
The Chinese cobra (Naja naja atra) belongs to the elapid family (Elapidae) with the characteristic “glasses” sign, which is one of China’s top ten poisonous snakes, and is mainly distributed south of the Yangtze River. The Mamushi or Fu-she (Agkistrodon halys), is one of the most widely distributed poisonous snakes in China. Other venomous species, such as the Chinese bamboo viper (Viridovipera stejnegeri), the Chinese krait (Bungarus multicinctus), and the Chinese habu (Protobothrops mucrosquamatus), are all common in China. 

Snakebites and their management in China have been reported to a certain extent. However, to the best of our knowledge, this is the first study to investigate knowledge of snakes and snakebites within members of the Chinese military. Our goal is to provide baseline data for understanding the current perception and knowledge of snakebites, and for improving medical education in order to decrease the morbidity and mortality rates of snakebites in China. To achieve this goal, we conducted a survey on the knowledge of snakebites among military personnel in a specific field troop in southeast China.

Design and Sample
The research was formed of a cross-sectional study. A convenience sample was taken from military personnel from a field troop in southeast China. Six platoons that didn’t operate under field conditions at this time were surveyed. A platoon is a military unit containing between 30 and 50 soldiers, and thus 216 military personnel were requested to participate in the study. Those who had engaged in health care were excluded from the study.

A questionnaire which could be understood by people with minimal reading ability was developed, based on Guidelines for the Management of Snakebites, American Heart Association and American Red Cross Guidelines for First-Aid, and the materials used to train medics in China. 

The questionnaire consisted of three parts: 

1.-   Demographic information
2.- Self-evaluation: about their current perceptions of snakebites and demands for knowledge of snakebites, knowledge acquisition approach, experience of snakebites, and their immediate reaction to the occurrence of a snakebite; 
3.- Knowledge about snakebites (seven questions), including general knowledge about snakebites, prevention, and first-aid for snakebites. 

Demographic characteristics:
All of the participants were male, and 97.2% were below 30 years old. Most of them (95.8%) were of Han nationality. Of the military personnel, 93.1% had served in the army for less than 10 years and approximately 95% had received an education higher than junior high school.

Self-Evaluation:
A total of 10.3% (n = 22) of individuals reported that they had experienced snakebites, out of which 4.2% (n = 9) had been bitten by snakes more than once. 

The survey revealed that military members generally received information on snakebites from the military medical education (89.7%), and they also used books, magazines, and newspapers (13.5%), television (8.5%), family and friends (8.4%), and Internet (7.5%), in order to access information. 
In response to self-evaluated current perceptions of snakebites, nearly three fifths of the participants (57.9%, n = 124) rated their knowledge as “average”, 35.1% (n = 75) rated their knowledge as “good”, and 7.0% (n = 15) rated their knowledge as “poor”. 
With regard to demands for knowledge on snakebites, most of the participants (86.4%, n = 185) rated this demand as “high”, whereas only three (1.4%) rated it as “low”, and the others (12.1%, n = 26) rated it as “moderate”. 
It was satisfying to note that upon the occurrence of a snakebite, most of the military personnel (93.9%, n = 201) chose to assess the patient’s condition and take action through simple interventions, while 5.6% (n = 12) selected to call for help from a military surgeon or medical corpsmen; only one respondent (0.5%) was too nervous to do anything.



RESULTS ON PREVENTION AND FIRST AID:

Questions
n (%) **
Which of the following behaviors are likely to cause a snakebite during field training?
① Wear proper shoes or boots and long trousers instead of sandals or bare-foot.
22 (10.3)
② Straight over rocks or logs rather than step on them. *
64 (29.9)
Do not use a light (torch, flashlight or lamp) when walking at night. *
113 (52.8)
④ Rest near the holes, nests and other hidden places. *
184 (86.0)
No response
3 (1.4)
The correct answers: ②③④
16 (7.5)
What would you do with the wound if someone suffered a snakebite?
① Rinsing (not scrubbing) the wound with water as soon as possible. *
188 (87.9)
Attempt to suck the venom out of the wound.
161 (75.2)
Application of ice packs.
60 (28.0)
Making local incisions at the site of the bite.
189 (88.3)
Application of alcohol.
57 (26.6)
⑥ Massage the bite wound.
10 (4.7)
The correct answers: ①
5 (2.3)
Apart from calling for help, which of the following first-aid measures would you take if someone suffered a snakebite?
Tell him/her to stay calm. *
166 (77.6)
Immobilize the victim’s whole body, especially the wounded limb. *
158 (73.8)
③ Raise the site of the bite above the level of the person’s heart.
28 (13.1)
Application of tight tourniquets around the upper part of the limb.
200 (93.5)
Applying a pressure immobilization bandage. *
37 (17.3)
No response
1 (0.5)
The correct answers: ①②⑤
2 (0.9)

* The correct answer; 
** The first number listed represents the number of responses and the number in parentheses represents the percentage number of responses.



DISCUSSION

Education on Snakebite

Our results showed that the snakebite knowledge of field force members mainly arose from military medical education, indicating that a well-designed and comprehensive medical training program, combined with updating international guidelines, should be implemented in order to convey the appropriate messages. Moreover, televisions, the Internet, and books, newspapers, and magazines, are all feasible methods for field force members to acquire information, and thus making full use of these media outlets contributes to a better understanding of snakebites. To our knowledge, the military medical education is usually given by medics, the most prominent source of the platoon’s healthcare knowledge. A lack of uniform and updated training materials distributed to the military personnel is probably the reason why there exists a gap in their knowledge of snakebites. 

Self evaluation
Despite more than one third (35%, n = 75) of the participants stating that they had a “good” knowledge of snakebites in the present study, only one of them was officially classified as “good” (0.5%), whereas the others were “average” (72.9%) or “poor” (26.6%), according to our score-based classification. 
The high prevalence of misperceptions of snakebite knowledge in field force members is alarming, because their perception could affect their preventive measures and first-aid. They may have great confidence in applying the appropriate first-aid on occurrence of the snakebite, but inversely, their measures may delay medical treatment or cause further harm This finding reinforces the significance of recognizing the misunderstanding of snakebite knowledge in field forces and conveying correct knowledge to those military personnel.

General Knowledge about Snakebites
General knowledge about snakebites within field force groups in this survey was not as satisfactory as expected. The rate of correct answers for “high-incidence period” was below 40%. Most of the field force members knew that snakebites occurred frequently during nighttime and summer, but were unaware that a number of snakebite cases occurred after the rain. Rain may wash debris and snakes into gutters at the edge of roads, hence, when walking after heavy rains, especially after dark, people should be careful.

Our study suggested that only around 30% of the participants were able to correctly identify all of these local and general manifestations of snakebite, indicating that their knowledge surrounding snakebite manifestations was fragmentary.

In our investigation, nearly 70% of the respondents could not identify the venomous snakes by the oval shaped head and regular teeth marks. We decided that the result arose from either their decision that the depicted characteristics of venomous snakes were incorrect, or their belief that it was unreasonable to identify the venomous snakes by their characteristics. Therefore, further research could be designed to explore the exact reason for this response and further information about snakes could be conveyed in order to eliminate their misunderstanding.

The Centers for Disease Control and Prevention recommends that people do not pick up a snake or try to trap it, because this carries the risk of a snakebite. It was gratifying that a vast majority of field force members were aware that even an accidental scratch from the fang of a snakes’ severed head may inject venom into their body.

Knowledge about Preventive Measures and First-Aid
The best treatment for snakebites is prevention. Preventive measures are recommended in snakebite prone regions. In our study, preventive measures such as wearing long pants and boots, especially when walking in undergrowth or in the dark, and never resting near the holes, nests, and other hidden places where snakes might rest, were well understood by the respondents. However, only one-half of the respondents were conscious of using a light when walking at night. What’s worse, more than three fifths of the participants chose to walk straight over, rather than step on, facing rocks or logs. Snakes may be sunning themselves on the side of rocks or logs, and thus, stepping on the rocks or logs could decrease the risk of being bitten.

First-aid aims to retard systemic absorption of venom, control dangerous and distressing early symptoms of envenoming, prevent complications, and preserve life, before victims receive medical care. 
When considering how to deal with the snakebite wound, a very high percentage of the respondents attempted to suck the venom out of the wound and make local incisions at the site of the bite, both of which are proved to be ineffective and even dangerous first-aid techniques. Similar useless and harmful methods, such as the use of ice packs and massaging the bite wound, were also selected by a small group of the respondents. Vigorous cleaning should be avoided as this may increase absorption of the venom and local bleeding, according to WHO guidelines. 

Reassuring the snakebite victim is recommended, as they may be very anxious and this form of first-aid had been adopted by more than three quarters of the respondents. A total of 73.8% of the investigated military personnel were aware of immobilizing the whole of the victim’s body, specifically the bitten limb, which is a desirable practice for decreasing venom absorption. 

Application of tourniquet is a dangerous intervention, carrying a high risk of well-known adverse consequences, such as ischemic damage and rhabdomyolysis, contributing to amputation and skin grafting. However, a substantial proportion of the respondents (93.5%) said that applying a tourniquet was a good idea. 

There is an urgent need to avoid inappropriate traditional treatments, including application of chemicals, herbs or ice packs, and use of (black) snake stones, which may delay presentation, distort the clinical picture, and even cause infection, gangrene, and other complications. Moreover, only a small number of the participants decided to apply a pressure immobilization bandage, a safe way to delay toxicity by slowing lymph flow, unless a neurotoxic elapid can be excluded. We consider that the unawareness of applying a pressure immobilization bandage results from a lack of confidence and a poor retention of the skill of pressure immobilization. It has been demonstrated that inadequate pressure is ineffective and too much pressure may cause local tissue damage, and once learned, retention of the skill of proper pressure and immobilization application is poor [19]. Accordingly, it is a challenge to find an effective way to teach the application of the correct snugness of the bandage, and we need to make it possible for military personnel to receive proper first-aid more quickly.

Above all, we suggest that the lack of applying WHO recommended first-aid, associated with an inclination of field force members to use incisions, tourniquets, and suck out the venom, offers an opportunity for military educational intervention.

Conclusions
Snakebites often occur in Chinese field forces. Our research revealed that snakebite knowledge within these field forces was inadequate and in some cases misleading when considering manifestation, prevention, and first-aid. Military personnel desired more information on snakebites. In order to address these issues, we suggest that a pragmatic, intensive educational effort should be focused on basic knowledge of snakes, prevention, and first-aid measures undertaken in these at-risk populations.


ॐ लोकाः समस्ताः सुखिनो भवन्तु ॥
Om Lokah Samasthah Sukhino Bhavantu
May all beings everywhere be happy and peaceful